Gene Virus Raises Risk of Aggressive Prostate Cancer

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1. Julian Lieb,M.D on September 8th, 2009 7:40 am

   DEFEATING CANCER

   Prostaglandins are infinitesimal, ephemeral and powerful signaling molecules that self-regulate the chemistry of every cell in the body, including cells regulating mood, and those regulating immune function. When produced within normal limits, prostaglandins regulate the physiology of every cell; when produced excessively, physiology becomes pathology. When brain cells produce excessive concentrations of prostaglandins, they depress mood and immunity. In 1973, David Horrobin showed that antidepressants inhibit prostaglandins, and in 1977 that prostaglandins regulate nucleic acids (DNA and RNA).1,2 Others subsequently showed that prostaglandins regulate the synthesis, inhibition, and expression of genes, and the growth and replication of cells, with cancer the accelerated replication of abnormal cells.1,2 Excessive synthesis of prostaglandins induces cancer, with genes determining the variations. In 1998 Brenda Penninx published a key study showing that age 70 chronically depressed people have an increased risk of 88% of developing cancer, and of 50% of dying of it.

   More than fifty studies have shown that antidepressants kill cancer cells, inhibit their proliferation, convert multidrug resistant cells to sensitive, protect nonmalignant cells from damage by radiation and chemotherapy toxicity, and target the mitochondria of cancer cells while sparing those of healthy ones.1,2 Antidepressants have therapeutic potential in many cancers that are often treatment resistant, such as gliomas, cancers of the lung, kidney, liver, and uterus, inflammatory breast cancer, and multiple myelomas.2 Antidepressants are capable of arresting cancer in advanced stages, and even reversing it. That antidepressants are effective for a multitude of malignancies, decries the myth that cancer is a hundred diseases, when it is one disease with a hundred variations. Antidepressants alleviate cancer pain, alone or combined with narcotics, remit nausea and vomiting, promote sleep, relieve anxiety and depression, and combat fatigue. Other inhibitors of prostaglandins, such as non-steroidal, anti-inflammatory drugs as aspirin, indomethacin, ibuprofen, and piroxicam, and COX-2 inhibitors, also have potential value in defeating cancer.

   The components are in place for a revolution in cancer prevention and treatment, as may be confirmed by accessing Medline or Pubmed, and entering “antidepressants” and “cancer.” Max Planck noted that the guardians of obsolete concepts so rarely concede to a promising newcomer, that change can only come about after they die. Paul Feyerabend wrote that suppressing a paradigm in preference to one politically favored could permanently damage society, and that resistance to progress could be so intractable that political intervention might be needed.
   Sincerely,
   Julian Lieb, M.D
   1Lieb, J.”The multifaceted value of antidepressants in cancer therapeutics.” Eur J Cancer. Editorial Comment. (2008) 172-174
   2Lieb, J.”Defeating cancer with antidepressants.” ecancermedicalscience DOI.10.3332/eCMS.2008.88

   {I am a retired, former Yale medical school professor, and author or coauthor of forty eight articles and nine books}.

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